Technical advantages and limitations
Advantages:
1. High sensitivity: It can detect fluorescence quenching, FRET, and changes electrical properties with high precision, and can detect biomolecules at the picomolar or even femtomolar level, providing support for early diagnosis of diseases and traceant detection.
2. Wide dynamic detection range: The luminescent properties are easy to regulate, and the response to different concentrations of target substances is linear, can accurately determine the content over a wide concentration range, meeting the detection needs of different concentrations such as environmental pollutants.
3. Good stability and reproducibility: It has good chemical and photostability, is less affected by environmental factors, has a controllable preparation process, similar performance between batches, and high reliability.
4. Convenient functionalization and integration: The surface is easy to modify, can specifically recognize target substances, and can be integrated with a variety of materials and devices to small, multi-functional sensor systems, which are convenient for rapid on-site detection and high-throughput analysis.
Disadvantages:
1.paration cost and quality consistency: The preparation technology is complex and costly, limiting large-scale applications; there are differences in the size and performance of quantum dots in different, affecting the stability and reliability of sensor performance, and it is necessary to optimize the process and improve quality control.
2. Biological safety is questionable: a nanomaterial, its biological toxicity and environmental impact are insufficiently studied, and it may interfere with physiological processes in vivo, and safety assessment is needed during application
3. Challenges in technology integration: There are compatibility issues when integrated with other technologies, such as when integrated with existing devices and systems, there are problems with matching, data transmission, and processing coordination, and it is necessary to develop compatible interfaces and integration technologies.
Technological development trends
Performance optimization:
1. Improve sensitivity and selectivity: Design efficient quantum dot structures, optimize surface modification strategies, enhance the specificity of interaction with target substances, develop new composite, and achieve simultaneous high-sensitivity detection of multiple target substances in complex samples.
2. Expand the detection range: Explore the application in the detection of pollutants, rare bio-markers, and other fields, and expand the detection range from common parameters to complex biological and environmental indicators.
Application expansion:
1.In-depth application in biomedicine: Disease diagnosis is developing towards early warning, precise diagnosis, and personalized treatment, combined with artificial intelligence and big data to achieve screening, classification, and prognosis assessment of diseases; in drug development, real-time monitoring of drug metabolism in vivo, and optimize design and administration.
2.Internet of Things and intelligent sensing: Widely used in smart home, smart city, and other fields, real-time monitoring of environmental parameters, equipment status, intelligent control, such as monitoring the indoor environment in smart buildings, and automatically adjusting the system.
Technology fusion and innovation
Integration with nan: Develop new structures such as quantum dot nanowires, nanoarrays, etc., and use nanotechnology to achieve precise assembly and integration, and build highperformance nanosensor systems.
Integration with artificial intelligence: Use artificial intelligence algorithms to deeply analyze
sensor data, achieve intelligent interpretation of detection results, fault diagnosis and, and optimize sensor design and detection processes through machine learning, and improve intelligence and detection efficiency.